Candidone
Candidone is a type of flavanone phenolic compound with anti-cancer and antibacterial activities. Candidone inhibits the proliferation of hepatoblastoma and cholangiocarcinoma cells and induces their apoptosis by up-regulating p21, Bax, and caspase 3/9, and down-regulating Bcl-2 and survivin. It reduces the metastatic ability of cancer cells by inhibiting the expression of phosphorylated p38 and matrix metalloproteinase MMP-9. Candidone has inhibitory effects on multidrug-resistant bacterial strains. Candidone binds to the base pairs of DNA in a groove-binding manner, thereby slightly altering the conformation of DNA[1][2][3].
Product Specifications
CAS Number
[77727-18-5]
UNSPSC
12352005
Target
Apoptosis; Bacterial; Bcl-2 Family; Caspase; DNA/RNA Synthesis; MMP; p38 MAPK; Survivin
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Field of Research
Cancer; Infection
Smiles
COC1=C2C(O[C@H](C3=CC=CC=C3)CC2=O)=C(C(OC)=C1)C/C=C(C)\C
Molecular Formula
C22H24O4
Molecular Weight
352.42
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-180324/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; Caspase 3; Caspase 9; MMP-9; p38 MAPK
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