SET-12

SET-12 is an antiparasitic agent with high activity and selectivity against the Leishmania amazonensis. SET-12 exhibits excellent activity against the pre-flagellated form of the Leishmania amazonensis, with an IC₅₀ of 10.89 μM and a selectivity index (SI) of up to 12.1. SET-12 is also effective against the non-flagellated form within cells, with an IC₅₀ of 3.81 μM and a further increased selectivity index (SI) to 34.5. SET-12 causes signs of parasite cell apoptosis, including mitochondrial damage and accumulation of ROS[1].

Product Specifications

CAS Number

[2241572-39-2]

UNSPSC

12352005

Target

Apoptosis; DNA/RNA Synthesis; Parasite; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Infection

Smiles

O=C1OC[C@H](C(C)C)N1C([C@H]([C@H](O)CCC2=CC=CC=C2)/C=C/CC)=O

Molecular Formula

C21H29NO4

Molecular Weight

359.46

References & Citations

[1]Calero-Docina IM, et al. Leishmanicidal and trypanocidal potential of ß, γ-unsaturated carboxylic acid synthetic derivatives. Eur J Med Chem. 2026 Feb 5;303:118390.