KD36
KD36 is a selective KRAS-G12C inhibitor with an IC50 value of 0.92 μM. KD36 can inhibit the phosphorylation of ERK and AKT, induce the accumulation of reactive oxygen species (ROS), reduce mitochondrial membrane potential, thereby leading to apoptosis of KRAS-G12C mutant cells. KD36 can be used in the research of non-small cell lung cancer (NSCLC) [1].
Product Specifications
UNSPSC
12352005
Target
Akt; Apoptosis; Mitochondrial Metabolism; PERK; Ras; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(C=C)N(CC1)CCN1C2=NC(OC[C@@H]3CCCN3C)=NC(C4=C(C=CC=C5)C5=CC(OC)=C4)=C2C#N
Molecular Formula
C29H32N6O3
Molecular Weight
512.60
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
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