ZS34
ZS34 is a potent, orally active, and selective MAT2A inhibitor with an IC50 of 13.7 nM, displaying minimal hERG and UGT1A1 liabilities. ZS34 selectively suppresses the growth of methylthioadenosine phosphorylase (MTAP) -deficient cancer cells by inhibiting SAM synthesis, reducing SDMA levels, and inducing DNA damage. ZS34 exhibits antitumor efficacy in a HCT116 MTAP-/- xenograft mouse model. ZS34 can be used for the research of MTAP-deficient cancer[1].
Product Specifications
CAS Number
[3106086-17-0]
UNSPSC
12352005
Target
Methionine Adenosyltransferase (MAT)
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C1N(C2=C(C(NC)=N1)C3=C(C(Cl)=C2)C=CO3)C4=CC=CC=C4C
Molecular Formula
C18H14ClN3O2
Molecular Weight
339.78
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Lentiviral human NHLRC3 sgRNA gene knockout kit - Lentiviral human NHLRC3 sgRNA gene knockout kit (plasmid)
