NDM-1-IN-11
NDM-1-IN-11 is a potent covalent NDM-1 inhibitor with an IC50 of 1.12 μM, which acts by forming a Se-S bond with the enzyme. NDM-1-IN-11 effectively suppresses the growth of NDM-1-producing E. coli in both in vivo and in vitro models when combined with Meropenem (HY-13678) . NDM-1-IN-11 can be used for addressing NDM-1 driven bacterial resistance[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial; Beta-lactamase
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C1N([Se]C2=CC=C(C=C21)OCC3=CC=CC([N+]([O-])=O)=C3)C4=C(C=CC=C4)C5=CC=C(C=C5)F
Molecular Formula
C26H17FN2O4Se
Molecular Weight
519.38
References & Citations
[1]Guo Y, et al. Structure-Directed Optimization of Ebselen Derivatives as Potent NDM-1 Inhibitors Reverses Meropenem Resistance. J Med Chem. 2025;68 (22) :24272-24293.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Metallo-β-lactamase (MBL)
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