TMU4142
TMU4142 is a selective 5-HT1a agonist with high GoA activity. TMU4142 has weak Gi3 activity, can elicit rapid antidepressant like effects without triggering significant activation of dorsal raphe nucleus (DRN) 5-HT1a R autoreceptors or serotonergic neuron firing. TMU4142 demonstrates fast-acting efficacy in mouse models of depression. TMU4142 can be used for antidepressants research[1].
Product Specifications
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O[C@@H](CNCCCN1C(CC2(CCCC2)CC1=O)=O)COC3=CC=CC4=C3C=CN4
Molecular Formula
C23H31N3O4
Molecular Weight
413.51
References & Citations
[1]Wang C, et al. Pathway-selective 5-HT1AR agonist as a rapid antidepressant strategy. Cell. 2025 Dec 11;188 (25) :7222-7237.e24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor
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