DL78
DL78 is an effective anti-mitotic agent. DL78 induces mitotic arrest, mitotic catastrophe and apoptosis in cancer cells by disrupting the interaction between Myc and α-tubulin. DL78 exhibits broad anti-cancer activity, especially against cancer cells with chromosomal instability and excessive expression of MYC. DL78 significantly reduces tumor burden in the OV81.2 xenograft model. DL78 can be used for the study of ovarian cancer[1].
Product Specifications
CAS Number
[132993-79-4]
UNSPSC
12352005
Target
Apoptosis; c-Myc; Microtubule/Tubulin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Smiles
O=C(C1=C(C)OC2=CC=C(OC)C=C12)C3=CC4=CC(OC)=CC=C4O3
Molecular Formula
C20H16O5
Molecular Weight
336.34
References & Citations
[1]Teitel J, et al. Pan-cancer Myc modulator that targets Myc-α-tubulin interaction to drive selective mitotic catastrophe. Sci Rep. 2025 Oct 31;15 (1) :38188.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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