ISR activator 2

ISR activator 2 is a selective ISR activator. ISR activator 2 can preferentially activate the ISR through the binding of the cytosolic pattern recognition receptor RIG-I, which subsequently activates the heme-regulated inhibitor (HRI) ISR kinase independent of an interferon response. ISR activator 2 can be used for the study of pancreatic cancer[1].

Product Specifications

CAS Number

[332874-88-1]

UNSPSC

12352005

Target

Eukaryotic Initiation Factor (eIF)

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer; Neurological Disease

Smiles

CC1=CC(C)=NC(SCC(NC2=C(C(OCC)=O)C(C3=CC=CC=C3)=CS2)=O)=C1C#N

Molecular Formula

C23H21N3O3S2

Molecular Weight

451.56

References & Citations

[1]Cuoco CA, et al. Pharmacological targeting of RIG-I can selectively activate the integrated stress response. Sci Adv. 2025 Oct 31;11 (44) :eadt3014.