JHU-58

JHU-58 is a peptidomimetic agonist targeting mouse MRGPRC11 and rat MRGPRC receptors. JHU-58 demonstrates analgesic effects in mouse models of neuropathic pain. JHU-58 is promising for research of neuropathic pain[1].

Product Specifications

CAS Number

[1632140-61-4]

UNSPSC

12352005

Target

Mas-related G-protein-coupled Receptor (MRGPR)

Related Pathways

GPCR/G Protein

Field of Research

Neurological Disease

Smiles

NC([C@H](CC1=CC=CC=C1)NC([C@H](N)CC2=CC=C(C=C2)NC(N)=N)=O)=O

Molecular Formula

C19H24N6O2

Molecular Weight

368.43

References & Citations

[1]Prchalová E, et al. Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists. J Med Chem. 2019 Sep 26;62 (18) :8631-8641.