Glucokinase activator 10

Glucokinase activator 10, a thiazole-based compound, is a liver-selective and orally active  glucokinase activator with an EC50 of 42 nM. Glucokinase activator 10 exhibits significant glucose lowering in acute diet-induced obese mouse oral glucose tolerance (OGTT) test. Glucokinase activator 10 can be used for the study of metabolic disorders[1].

Product Specifications

UNSPSC

12352005

Target

Glucokinase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=S(C1=CC=C(OC2=CC(C(NC3=NC(CCCOP(C)(C)=O)=CS3)=O)=CC(O[C@@H](C)COC)=C2)C=N1)(C)=O

Molecular Formula

C25H32N3O8PS2

Molecular Weight

597.64

References & Citations

[1]Yoon DS, et al. Discovery of liver-selective glucokinase activators comprising N- (4-alkylthiazol-2-yl) benzamides and N- (3-alkyl-1,2,4-thiadiazol-5-yl) benzamides for the treatment of metabolic disorders. Bioorg Med Chem Lett. 2025 Jul 1;122:130192.