CypD-IN-7
CypD-IN-7 is a potent cyclophilin D (CypD/PPIF) inhibitor that inhibits CypD PPIase activity (Ki = 2.4 nM) and provides protection against mitochondrial permeability transition pore (MPTP) opening. CypD-IN-7 can be used for pancreatitis research[1].
Product Specifications
UNSPSC
12352005
Target
Cyclophilin
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
FC1=CC=C(C(N2CCCN2C([C@@H](NC(NCC3=CC4=C(N[C@H]5[C@H](O)CO[C@@H]4C5)C=C3)=O)C6=CC=C(C7=CC=C(CN8CCOCC8)C=C7)C=C6)=O)=C1)Cl
Molecular Formula
C41H44ClFN6O5
Molecular Weight
755.28
References & Citations
[1]Awais M, et al. Potent Preorganized Pyrazolidine Cyclophilin D Inhibitors Prevent Mitochondrial and Organ Injury in a Mouse Pancreatitis Disease Model. J Med Chem. 2025;68 (22) :23910-23924. doi:10.1021/acs.jmedchem.5c01146
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cyclophilin D
Curated Selection
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