MC3817

MC3817 is a selective DNMT1 inhibitor. MC3817 inhibits DNMT1 and DNMT3A/3L with IC50s of 0.044 μM and > 10μM, respectively. MC3817 inhibits P53-dependent cancer cell proliferation, induces apoptosis and DNA damage MC3817 elevates cleaved Caspase 3, P53, and γH2AX. MC3817 can be used in non-small cell lung cancer, colon cancer, cervical cancer, triple-negative breast cancer and histiocytic lymphoma research[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Caspase; DNA Methyltransferase; DNA/RNA Synthesis; MDM-2/p53

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

O=C(NC1=CC(CN(C)C)=CC(NC2=NC(N)=NC(C)=C2)=C1)C3=CC(CN(C)C)=CC(NC4=C5C=CC=CC5=NC=C4)=C3.Cl.Cl.Cl.Cl

Molecular Formula

C33H41Cl4N9O

Molecular Weight

721.55

References & Citations

[1]Zwergel C, et al. Quinoline-Based DNA Methyltransferase Inhibitors Featuring Basic Side Chains: Design, Synthesis, and Insight in Biochemical and Anticancer Cell Properties. J Med Chem. 2025 Nov 27;68 (22) :23886-23909.