T-1228
T-1228 is a highly selective LpxC inhibitor. T-1228 can effectively block the synthesis of LPS (HY-D1056), causing defects in the bacterial outer membrane structure, increasing membrane permeability, and ultimately leading to bacterial cell death. T-1228 can be used for the study of Gram-negative bacterial infections[1].
Product Specifications
CAS Number
[1884551-35-2]
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(N(C)[C@](C(NC)=O)(C)C(NO)=O)C(C=C1)=CC=C1C#CC2=CC=C([C@H](O)CO)C=C2.O
Molecular Formula
C23H27N3O7
Molecular Weight
457.48
References & Citations
[1]Nagato Y, Nakajima N. Process Development of the Novel LpxC Inhibitor T-1228. Part 4: Control of Mutagenic Impurities during API Synthesis. Organic Process Research & Development. 2025 Nov 20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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