KMCA-0011
KMCA-0011 is an orally active ɑ2C adrenoceptor antagonist (Ki = 56.7 nM) . KMCA-0011 alleviates depressive behaviors by enhancing BDNF and synaptic plasticity. KMCA-0011 displays favorable metabolic stability, including high plasma stability (99.8% after 120 min) . KMCA-0011 can be used for the research of depression[1].
Product Specifications
UNSPSC
12352005
Target
Adrenergic Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
ClC1=CC=C(OC(C(NCCN2CCC(CC3=CC=CC=C3)CC2)=O)=N4)C4=C1
Molecular Formula
C22H24ClN3O2
Molecular Weight
397.90
References & Citations
[1]Seo K, et al. ɑ2C Adrenoceptor antagonist KMCA-0011 alleviated depressive-like behaviors in a maternal separation mouse model. Bioorg Med Chem Lett. 2026 Feb 1;131:130467.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α adrenergic receptor
Curated Selection
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