PLTP-IN-1

PLTP-IN-1 (cpd B) is a selective phospholipid transfer protein (PLTP) inhibitor with an IC50 of 1.6 μM. PLTP-IN-1 can block the phospholipid transfer mediated by PLTP and reduce the secretion of apolipoprotein B. PLTP-IN-1 has no effect on the level of triglycerides. PLTP-IN-1 can be used for the research of metabolic disease, such as hyperlipidemia[1].

Product Specifications

CAS Number

[1224565-08-5]

UNSPSC

12352005

Target

Apolipoprotein

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Smiles

FC1=CC=CC(CN2C3C4=C(C2CN(C3)CC5=CC=C(C(OCC)=C5)OC)C=CC=C4)=C1

Molecular Formula

C27H29FN2O2

Molecular Weight

432.53

References & Citations

[1]Luo Y, et al. Pharmacologic inhibition of phospholipid transfer protein activity reduces apolipoprotein-B secretion from hepatocytes. J Pharmacol Exp Ther. 2010 Mar;332 (3) :1100-6.