SDH-IN-42

SDH-IN-42 (Compound D28) is a SDH (IC50: 5.38 μg/mL) inhibitor and antifungal agent. SDH-IN-42 exerts antifungal activity against R. solani by disrupting mycelial morphology, increasing cell membrane permeability, inducing the production and accumulation of ROS, and impairing mitochondrial function[1].

Product Specifications

UNSPSC

12352005

Target

Fungal; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

O=C(C1=NOC(/C=C/C2=C(C)CCCC2(C)C)=C1)NNC3=CC=C(F)C(F)=C3

Molecular Formula

C21H23F2N3O2

Molecular Weight

387.42

References & Citations

[1]Su S, et al. Novel β-Ionone Derivatives Containing Isoxazole Hydrazide Moiety: Design, Synthesis, Antifungal Activity, and Action Mechanism. J Agric Food Chem. 2025 Nov 12;73 (45) :29160-29170.