MIPS3526
MIPS3526 is a potent and selective A2B adenosine receptor (A2BR) agonist with a pEC50 of 10.17 (EC50 of 58 pM) . MIPS3526 shows highly receptor subtype selective versus the A1R, A2AR, and A3R. MIPS3526 ameliorates angiotensin II stimulating effects in both cardiac myocytes and fibroblasts. MIPS3526 can be used for the study of cardiovascular disease including heart failure where cardiac remodeling is a major driver[1].
Product Specifications
UNSPSC
12352005
Target
Adenosine Receptor
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Smiles
NC(S1)=C(C(C2=CC=CC=C2)=O)C(C3=CC(C(F)(F)F)=CC=C3)=C1C(C=C4)=CC=C4C(N=N5)=CN5CCCCCCNC6=NC=NC7=C6N=CN7[C@@H]8O[C@H](C(NCC)=O)[C@@H](O)[C@H]8O
Molecular Formula
C44H43F3N10O5S
Molecular Weight
880.94
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR) ; Adenosine A2B receptor (A2BR) ; Adenosine A3 receptor (A3R)
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