DEL-C1

DEL-C1 is a CHI3L1 inhibitor. DEL-C1 can restore the ability to clear Amyloid-β and repair lysosomal function of astrocytes. DEL-C1 can inhibit NF-κB signaling and IL-6 secretion. DEL-C1 can be used for the researches of inflammation and neurological disease, such as Alzheimer's disease[1].

Product Specifications

UNSPSC

12352100

Target

Amyloid-β; Glycosidase; Interleukin Related; NF-κB

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

CNC(C[C@H](C1=CC=CC=C1)NC(C[C@@H](NC([C@@H]2CCCC[C@H]2NCC3=CN=C(O3)C4=C(N=C(S4)C)C)=O)CC5=CNC6=C5C=CC=C6)=O)=O

Molecular Formula

C38H45N7O4S

Molecular Weight

695.87

References & Citations

[1]Kaur B, et al. Discovery of a CHI3L1-Targeted Small Molecule Modulating Neuroinflammation in Alzheimer's Disease via DNA-Encoded Library (DEL) Screening †. bioRxiv [Preprint]. 2025 Oct 21:2025.10.20.683491.