CT-179
CT-179 is an OLIG2 inhibitor with brain permeability and oral availability. CT-179 inhibits its transcriptional activity by disrupting OLIG2 dimerization, phosphorylation, and DNA binding. CT-179 induces G2/M phase arrest, promotes apoptosis, and differentiation in tumor cells. CT-179 can be used for cancer research[1].
Product Specifications
CAS Number
[1996636-69-1]
UNSPSC
12352005
Target
Apoptosis; OLIG2
Related Pathways
Apoptosis; Neuronal Signaling
Field of Research
Cancer
Smiles
CC1=NC(NC(NC2=CC(Cl)=C(C=C2)Cl)=O)=NC(NCCCN(C)C)=C1
Molecular Formula
C17H22Cl2N6O
Molecular Weight
397.30
References & Citations
[1]Li Y, et al. Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179. Nat Commun. 2025 Feb 4;16 (1) :1091.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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