VU0494372
VU0494372 is an activator of potassium ion channel KCNQ1. VU0494372 can significantly enhance the cell surface expression and transport efficiency of KCNQ1. VU0494372 does not alter KCNQ1 mRNA levels and protein degradation rate, and has no significant cytotoxicity. VU0494372 can be used for research on cardiovascular conditions[1].
Product Specifications
CAS Number
[882235-30-5]
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Smiles
CN1CCN(CC1)CC(COC2=CC=C(C=C2)C(C)(CC(C)(C)C)C)O
Molecular Formula
C22H38N2O2
Molecular Weight
362.55
References & Citations
[1]Clowes Moster K R, et al. High Throughput Screening Identifies a Small Molecule Trafficking Corrector for Long-QT Syndrome Associated KCNQ1 Variants[J]. bioRxiv, 2025: 2025.10. 13.682066.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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