LAG-3 PROTAC-1
LAG-3 PROTAC-1 is a potent LAG-3 PROTAC degrader with a DC50 of 0.27 μM. LAG-3 PROTAC-1 can be used in cancer immunology research (pink: LAG-3 ligand (HY-179061) ; blue: CRBN ligand (HY-10984) ; black: linker; CRBN ligand + linker (HY-131888A) ) [1].
Product Specifications
UNSPSC
12352005
Target
LAG-3; PROTACs
Related Pathways
Immunology/Inflammation; PROTAC
Field of Research
Cancer
Smiles
O=C(NCCCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)[C@H]([C@@H](C4=CC=CC=C4)C5)CN5CC6=CC=CC=N6
Molecular Formula
C34H36N6O5
Molecular Weight
608.69
References & Citations
[1]Vázquez NG, et al. Design and validation of the first-in-class PROTACs for targeted degradation of the immune checkpoint LAG-3. Bioorg Med Chem Lett. 2025 Oct 4;130:130428.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Curated Selection
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