JOSD2-IN-1
JOSD2-IN-1 (Compound 31) is a covalent JOSD2 inhibitor with an IC50 value of 1.95 μM. JOSD2-IN-1 inhibits JOSD2, thereby down-regulating KRAS expression. JOSD2-IN-1 exhibits significant anti-proliferative activity against HCT116 cells. JOSD2-IN-1 can be used for research on colorectal cancer[1].
Product Specifications
UNSPSC
12352005
Target
Deubiquitinase; Ras
Related Pathways
Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway
Field of Research
Cancer
Smiles
O=C(C1=C2NC(NC([C@@H]3[C@@]4([H])CN(C#N)C[C@@]34[H])=O)=NC2=CC=C1)NC56CC7(C)CC(C6)(C)CC(C7)C5
Molecular Formula
C27H32N6O2
Molecular Weight
472.58
References & Citations
[1]Liu P, et al. Rational DESIGN and Structure-activity relationship study of novel JOSD2 inhibitor against colorectal cancer. Bioorg Chem. 2025 Oct 5;166:109022.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Curated Selection
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