MH44
MH44 is an efficient inhibitor targeting the SARS-CoV-2 nsp14 N7-methyltransferase (N7-MTase) with an IC50 of 19 nM. MH44 exhibits moderate antiviral effects in SARS-CoV-2-infected A549-hACE2 cells and shows certain cytotoxicity at higher concentrations. MH44 can be used in the research on anti-SARS-CoV-2[1].
Product Specifications
CAS Number
[2766190-68-3]
UNSPSC
12352005
Target
DNA Methyltransferase; SARS-CoV
Related Pathways
Anti-infection; Epigenetics
Field of Research
Infection
Smiles
O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1CN(S(=O)(C4=CC(C#N)=C(OC)C=C4)=O)CC
Molecular Formula
C20H23N7O6S
Molecular Weight
489.50
References & Citations
[1]Hausdorff M, et al. Synthesis and in vitro inhibitory activity of N-arylsulfonamide adenosine analogues designed to target SARS-CoV-2 nsp14 N7-methyltransferase. Bioorg Chem. 2025 Oct 14;166:109104.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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