PGK1-IN-2

PGK1-IN-2 (Compound 60) is a PGK1 inhibitor with an IC50 of 8.24 μM. PGK1-IN-2 demonstrates a significant ability to inhibit the proliferation of osteosarcoma cells. PGK1-IN-2 interferes with the glycolytic pathway of tumor cells by inhibiting PGK1. PGK1-IN-2 inhibits cell migration and invasion, and induces cell S phase and G2-M phase cycle arrest. PGK1-IN-2 may kill cells by inducing cuproptosis. PGK1-IN-2 shows a significant anti-tumor effect in the MNNG-HOS osteosarcoma xenograft mouse model. PGK1-IN-2 can be used for the study of osteosarcoma[1].

Product Specifications

CAS Number

[3054148-68-1]

UNSPSC

12352005

Target

Cuproptosis; Phosphoglycerate Kinase (PGK)

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

COCCCCNC(C1=NC(C2N(C3=NC=CC=C3OC)C(CS2)=O)=CC=C1)=O

Molecular Formula

C20H24N4O4S

Molecular Weight

416.49

References & Citations

[1]Chen X, et al. Thiazolidinones as Potential PGK1 Inhibitors for Treatment of Osteosarcoma Growth and Metastasis. J Med Chem. 2025 Nov 13;68 (21) :22216-22245.