BJH-60

BJH-60 is a mitochondrial complex 1 inhibitor. BJH-60 can inhibit mitochondrial oxygen consumption rate with an IC50 of 1.9 μM in A549 cells. BJH-60 shows no PDE inhibitory effect. BJH-60 can be used for the research of cancer, such as breast cancer[1].

Product Specifications

CAS Number

[3067849-06-0]

UNSPSC

12352005

Target

Mitochondrial Metabolism

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

OCC1=CC=C(C2=CC=CC(CC3=CC=NC4=CC=C(OC)C=C34)=C2)C=C1

Molecular Formula

C24H21NO2

Molecular Weight

355.43

References & Citations

[1]Haines BJ, et al. Development of Selective and Soluble Mitochondrial Complex 1 Inhibitors Derived from Papaverine for Radiosensitization of Cancer. J Med Chem. 2025;68 (21) :23140-23162.