YL6113
YL6113 is a potent and selective dual inhibitor of metallo-β-lactamases (MBLs) and serine-β-lactamases (SBLs) . YL6113 shows inhibitory effect to MBLs, such as NDm-1, VIM-2, IMP-1, with IC50 values of 0.25, 27.16 and 3.55 μM. YL6113 shows inhibitory effect to SBLs, such as KPC-2, AmpC, OXA-48, with IC50 values of 0.2, 34.1 and 1.31 μM. YL6113 enhances the antibacterial efficacy of Meropenem (HY-13678) against carbapenem-resistant Gram-negative bacteria. YL6113 can be used for the research of infection[1].
Product Specifications
UNSPSC
12352005
Target
Beta-lactamase
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
NCC1=CC=C(C=C1)C2=CN(N=N2)CC3=CC=C4OCB(OC4=C3C(O)=O)O.Cl
Molecular Formula
C18H18BClN4O5
Molecular Weight
416.62
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Metallo-β-lactamase (MBL) ; Serine β-lactamase (SBL)
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
