PROTAC GPX4 degrader-5
PROTAC GPX4 degrader-5 is an efficient and highly selective GPX4 PROTAC degrader (DC50 = 28 nM) . PROTAC GPX4 degrader-5 can induce ferroptosis and has low toxicity to normal cells. PROTAC GPX4 degrader-5 can significantly increase ROS. PROTAC GPX4 degrader-5 exerts anti proliferative effects on various tumor cells. PROTAC GPX4 degrader-5 is commonly used in cancer research. (Pink: GPX4 Ligand (HY-179294) ; Blue: Hyt Hydrophobic group (HY-N2427) ; Black: Linker (HY-W047688) ) [1]
Product Specifications
UNSPSC
12352100
Target
Ferroptosis; Glutathione Peroxidase; PROTACs; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PROTAC
Field of Research
Cancer
Smiles
O=C(NCCC1=CC=CC=C1)C(C2=CC=CS2)N(C3=CC=C(C(Cl)=C3)OCC(NCCCCCCCCCCNC(CC4(C[C@@H]5C6)C[C@H](C5)C[C@H]6C4)=O)=O)C(C#C)=O
Molecular Formula
C47H59ClN4O5S
Molecular Weight
827.51
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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