PROTAC GPX4 degrader-5

PROTAC GPX4 degrader-5 is an efficient and highly selective GPX4 PROTAC degrader (DC50 = 28 nM) . PROTAC GPX4 degrader-5 can induce ferroptosis and has low toxicity to normal cells. PROTAC GPX4 degrader-5 can significantly increase ROS. PROTAC GPX4 degrader-5 exerts anti proliferative effects on various tumor cells. PROTAC GPX4 degrader-5 is commonly used in cancer research. (Pink: GPX4 Ligand (HY-179294) ; Blue: Hyt Hydrophobic group (HY-N2427) ; Black: Linker (HY-W047688) ) [1]

Product Specifications

UNSPSC

12352100

Target

Ferroptosis; Glutathione Peroxidase; PROTACs; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PROTAC

Field of Research

Cancer

Smiles

O=C(NCCC1=CC=CC=C1)C(C2=CC=CS2)N(C3=CC=C(C(Cl)=C3)OCC(NCCCCCCCCCCNC(CC4(C[C@@H]5C6)C[C@H](C5)C[C@H]6C4)=O)=O)C(C#C)=O

Molecular Formula

C47H59ClN4O5S

Molecular Weight

827.51

References & Citations

[1]Ning Y, et al. Design, synthesis, and biological evaluation of ML162-based glutathione peroxidase 4 (GPX4) degraders with hydrophobic tags. Eur J Med Chem. 2026 Jan 5;301:118269.