ABD0171

ABD0171 is an effective ALDH inhibitor. ABD0171 can increase ROS levels and induce cell apoptosis. ABD0171 exhibits significant cytotoxicity in various glioblastoma (GB) cell lines, with EC50 ranging from 2.47 to 11.78 µM. ABD0171 can be used for cancer research[1].

Product Specifications

CAS Number

[2595201-23-1]

UNSPSC

12352005

Target

Aldehyde Dehydrogenase (ALDH) ; Apoptosis; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

CSC(C#CC(C)(N(CCOCC1=CC(C)=C(C=C1)C)C)C)=O

Molecular Formula

C19H27NO2S

Molecular Weight

333.49

References & Citations

[1]Jiménez R, et al. Targeting Retinaldehyde Dehydrogenases to Enhance Temozolomide Therapy in Glioblastoma. Int J Mol Sci. 2024 Oct 26;25 (21) :11512.