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BION106

BION106 is a dihydrofolate reductasethymidylate synthase (DHFR-TS) PROTAC degrader. BION106 exhibits extremely strong anti-malarial activity with a Ki and toxicity of 2.68 nM and 0.2 μM against Plasmodium falciparum, and > 100 μM and 44.2 μM in mammalian cells. BION106 can be used for the study of antimalarial parasites (Pink: DHFR-TS ligand (HY-15676) ; Blue: Idasanutlin ligand (HY-153007) ; Black: Linker (HY-W021401) ) [1].

Product Specifications

CAS Number

[3077918-44-3]

UNSPSC

12352005

Target

Dihydrofolate reductase (DHFR) ; Parasite; PROTACs

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; PROTAC

Field of Research

Infection

Smiles

N#C[C@@]1(C2=C(C=C(C=C2)Cl)F)[C@@H](C3=C(C(Cl)=CC=C3)F)[C@@H](N[C@H]1CC(C)(C)C)C(NC4=C(C=C(C=C4)C(NCCOCCOCCOCCNC(CCC5=C(C=CC=C5)OCCCOC6=C(N)N=C(N)N=C6CC)=O)=O)OC)=O

Molecular Formula

C57H69Cl2F2N9O9

Molecular Weight

1133.12

References & Citations

[1]Nitipol SRIMONGKOLPITHAK, et al. HYBRID MOLECULES BETWEEN PYRIMIDINE DERIVATIVES AND IDASANUTLIN FIELD OF INVENTION. WO2025053796A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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