SHR0687

SHR0687 is a selective tetrapeptide kappa opioid receptor (KOR) agonist with an EC50 of 0.53 pM. SHR0687 displays high potency and selectivity over MOR and DOR, with negligible blood-brain barrier penetration. SHR0687 activates KOR specifically, leading to potential modulation of neurological pathways without significant central nervous system effects. SHR0687 can be used for the research of pain[1].

Product Specifications

CAS Number

[2168573-03-1]

Target

Opioid Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

C[C@H](C1=CC=CC=C1)CNCC(N[C@H](CC2=CC=CC=C2)C(N[C@H](CC(C)C)C(N[C@H](CCCCN)C(N3CCC(CC3)NC(NC)=O)=O)=O)=O)=O

Molecular Formula

C39H60N8O5

Molecular Weight

720.94

References & Citations

[1]Li X, et al. Discovery of SHR0687, a Highly Potent and Peripheral Nervous System-Restricted KOR Agonist. ACS Med Chem Lett. 2020;11 (11) :2151-2155. Published 2020 Sep 14.