WML-01
WML-01 is a fungicide with EC50s of 0.079, 0.72 and 2.02 μg/mL against F. graminearum, F. fujikuroi and S. sclerotiorum. WML-01 disrupts the cell membrane of F. graminearum and induces deposition of lipid droplets. WML-01 inhibits Deoxynivalenol (DON) (HY-N6684) biosynthesis with no cross-resistance and strongly suppresses ribosomal subunit assembly, impairing protein synthesis. WML-01 effectively controls the fusarium head blight (FHB) epidemic[1].
Product Specifications
CAS Number
[3057478-36-8]
UNSPSC
12352005
Target
Fungal
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
CC1=C(C(OC12CCCCC2)=O)/C(C)=C3SC(NC/3=O)=S
Molecular Formula
C15H17NO3S2
Molecular Weight
323.43
References & Citations
[1]Li Y, et al. Discovery of WML-01, a Spirocyclic Butenolide Derivative Featuring a Rhodanine Motif, Exhibiting High Fungicidal Activity against Fusarium Species. J Agric Food Chem. 2025 Oct 15;73 (41) :25805-25812.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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