SDH-IN-36

SDH-IN-36 (Compound 17) is a derivative of alpha-D-tocopherol. SDH-IN-36 increases ROS and induces apoptosis by inhibiting SDHC and blocking electron transfer. SDH-IN-36 can inhibit the proliferation of various tumor cells, such as SSK4 (GI50 = 0.156 µM), SSNU638 (GI50 = 0.659 µM), and SKATOIII (GI50 = 0.490 µM) cells. SDH-IN-36 can significantly inhibit tumor growth. SDH-IN-36 can be used for research on cancers such as gastric cancer[1].

Product Specifications

CAS Number

[261929-60-6]

UNSPSC

12352005

Target

Apoptosis; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

CC1=C2CC[C@](OC2=C(C(C)=C1OCC(N)=O)C)(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C

Molecular Formula

C31H53NO3

Molecular Weight

487.76

References & Citations

[1]Kim Y, et al. Synthesis and biological evaluation of α-D-tocopherol derivatives as anticancer agents targeting mitochondrial metabolism. Eur J Med Chem. 2025 Dec 5;299:118081.