BGC1614

BGC1614 is a Nectin-4-targeting bicyclic toxin conjugate (BTC) belonging to the category of peptide-drug conjugates (PDCs) . BGC1614 exhibits strong targeted binding ability to Nectin-4, with an KD of 3.859 x 10-7 M. BGC1614 exhibits superior antitumor efficacy in nude mice bearing PC-3 and N87 tumor xenografts. BGC1614 can be used for research related to Nectin-4-overexpressing tumors (such as prostate cancer, gastric cancer) [1].

Product Specifications

UNSPSC

12352005

Target

Nectin-4

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(NCCCC[C@H](NC(COCCOCCOCCOCCOCCOCCNC(CN(C)C(CN(C)C(CN(C)C(CN(C)C(CN(C)C(CN(C)C(CN(C)C(CN(C)C(CN(C)C(CN(C)C([C@@H](NC([C@@H](NC([C@@H]1C[C@@H](O)CN1C([C@@H]2CCCN2C([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]3CCCN3C(CCSCCC(N4CN5CN6C4)=O)=O)=O)CC7=CC=CC8=C7C=CC=C8)=O)CC(O)=O)=O)CSCCC5=O)=O)CCSC)=O)CCCCNC(N)=N)=O)=O)CC9=CNC%10=CC=CC=C%109)=O)CO)=O)[C@@H](C)O)=O)=O)=O)CC%11=CNC%12=CC=CC=C%12%11)=O)CSCCC6=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(N)=O)[C@@H](NC(CCCC(N[C@H](C(N[C@H](C(NC%13=CC=C(COC(N([C@H](C(N[C@H](C(N([C@H]([C@H](OC)CC(N%14CCC[C@H]%14[C@H](OC)[C@H](C(N[C@@H]([C@H](C%15=CC=CC=C%15)O)C)=O)C)=O)[C@H](CC)C)C)=O)C(C)C)=O)C(C)C)C)=O)C=C%13)=O)CCCNC(N)=O)=O)C(C)C)=O)=O)CCCCN%16N=NC(C%17=C%18C=CC=C%17)=C%16C%19=C(CN%18C(CCC(NCCOCCOCCOCCOCCOCCOCC(NCCC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N[C@H](C(N[C@@H](CCCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@@H](CSCCC(N%20CN%21CN%22C%20)=O)C(N%23C[C@@H](C[C@H]%23C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](C(N%24[C@@H](CCC%24)C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N%25CCC[C@H]%25C(N[C@H](CC(O)=O)C(N[C@@H](CC%26=CNC%27=CC=CC=C%26%27)C(N[C@@H](CCCCNC(N)=N)C(NCCSCCC%22=O)=O)=O)=O)=O)=O)CC%28=CNC=N%28)=O)CC(C)C)=O)CSCCC%21=O)=O)CC(C)C)=O)=O)CC(N)=O)=O)=O)=O)O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C=CC=C%19

Molecular Formula

C387H582N94O104S7

Molecular Weight

8439.78

References & Citations

[1]Gu JN, et al. Design, synthesis and antitumor evaluation of a novel nectin-4 targeting bicyclic toxin conjugate. Bioorg Med Chem Lett. 2025 Nov 1;127:130306.