MFDCH016
MFDCH016 is a potent HDAC1/6 (IC50 = 38/59 nM) and CDK4/6 (IC50 = 680/720nM) inhibitor. MFDCH016 induces apoptosis and cell cycle arrest in G2/M and G0/G1 phases in MCF-7 cells. MFDCH016 can modulate the HDAC-p21-CDK signaling pathway, increasing the levels of acetylated H3 and p21. MFDCH016 can be used for the study of breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; CDK; HDAC; Histamine Receptor
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC(C1=C(C2=CN=C(N=C2N(C1=O)C3CCCC3)NCCC4CCN(CC4)C5=NC=C(C=N5)C(NO)=O)C)=O
Molecular Formula
C27H34N8O4
Molecular Weight
534.61
References & Citations
[1]Kim B, et al. Design and synthesis of novel cyclin-dependent kinase 4/6 (CDK4/6) and histone deacetylase (HDAC) dual inhibitors: In vitro and in vivo anticancer activity. Eur J Med Chem. 2025 Sep 21;301:118192.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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