SEH/PPARδ modulator 1
SEH/PPARδ modulator 1 is a sEH/PPARδ dual modulator. sEH/PPARδ modulator 1 can inhibit sEH with an IC50 of 0.46 μM and activate PPARδ with an EC50 of 0.12 μM. sEH/PPARδ modulator 1 can be used for the researches of inflammation, metabolic and cardiovascular disease[1].
Product Specifications
UNSPSC
12352101
Target
Epoxide Hydrolase; PPAR
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Smiles
CC1=CC(C(F)(F)F)=CC=C1NC(NCCOC2=CC=C(C=C2)CCC(O)=O)=O
Molecular Formula
C20H21F3N2O4
Molecular Weight
410.39
References & Citations
[1]Ge X, et al. Development of Potent and Selective Dual PPARδ/sEH Modulators from an AI-Designed Scaffold. J Med Chem. 2025 Oct 9;68 (19) :20636-20656.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARδ
Curated Selection
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