T2M-010
T2M-010 is a potent, brain-penetrant TREM2 agonist (Kd = 0.83 μM) . T2M-010 activates receptor-proximal signaling, inducing SYK phosphorylation in TREM2-expressing cells, and promotes microglial phagocytosis. T2M-010 can be used for the study of protective microglial responses relevant to Alzheimer’s disease (AD) [1].
Product Specifications
CAS Number
[364611-21-2]
UNSPSC
12352005
Target
Syk; TREM receptor
Related Pathways
Immunology/Inflammation; Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
C1(CCNC2=NC(C3=CNC4=C3C=CC=C4)=CS2)=CC=CC=C1
Molecular Formula
C19H17N3S
Molecular Weight
319.42
References & Citations
[1]Cho S, et al. AI-Assisted Discovery and Optimization of Small Molecule TREM2 Agonists with Functional Microglial Activity. bioRxiv [Preprint]. 2025 Sep 17:2025.09.11.675743.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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