E0199

E0199 is a novel potent dual-target KV7/NaV modulator that activates the KV7 channel (KV7.2/7.3 (EC50 = 12.78 nM), KV7.2 (EC50 = 0.50 μM), and KV7.5 (EC50 = 27.14 nM) channels) while simultaneously blocks the NaV1.7 (IC50 = 0.52 μM), NaV1.8 (IC50 = 0.24 μM), and NaV1.9 (IC50 = 0.16 μM) channels. E0199 shows a potent analgesic effect without affecting heart and skeletal muscle ion channels critically in a chronic constriction injury (CCI) mouse model. E0199 can be used for Neuropathic pain (NP) research[1].

Product Specifications

CAS Number

[931928-13-1]

UNSPSC

12352005

Target

Potassium Channel; Sodium Channel

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

COC1=C(C=CC(CC(N2CCN(CC2)CC3=NOC(CCC(N(CC4=CC=CC=C4)CC)=O)=N3)=O)=C1)OC

Molecular Formula

C29H37N5O5

Molecular Weight

535.63

References & Citations

[1]Zhang B, et al. Discovery of E0199: A novel compound targeting both peripheral NaV and KV7 channels to alleviate neuropathic pain. J Pharm Anal. 2025 Jan;15 (1) :101132.