ARUK2010694
ARUK2010694 (Compound 20) is a potent and selective NUAK1 inhibitor with a pIC50 of 8.7. ARUK2010694 also inhibits CDK2, CDK4 and CDK6 activity, with inhibitory rate of 13%, 63% and 32% at 1 μM. ARUK2010694 can be used for the research of neurological disease, such as Alzheimer’s disease (AD) [1].
Product Specifications
UNSPSC
12352005
Target
AMPK; CDK
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Field of Research
Neurological Disease
Smiles
CC(N1CCN(C2=CC=C(NC3=NC(OCC4CC(C)(C)OCC4)=C5N=CNC5=N3)C=C2)CC1)C
Molecular Formula
C26H37N7O2
Molecular Weight
479.62
References & Citations
[1]Gregory G. et al. Development of Purine and Pyrrolopyrimidine Scaffolds as Potent, Selective, and Brain Penetrant NUAK1 Inhibitors ACS Medicinal Chemistry Letters Article ASAP
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK4; CDK6; NUAK1
Curated Selection
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