Apoptosis inducer 46

Apoptosis inducer 46 is an apoptosis inducer. Apoptosis inducer 46 exhibits potent and selective growth inhibitory effects on metastatic triple-negative breast cancer (TNBC) cells. Apoptosis inducer 46 induces G2/M phase cell cycle arrest and apoptotic cell death in MDA-MB-231 cells, and blocks NF-κB nuclear translocation. Apoptosis inducer 46 can be used for the study of TNBC[1].

Product Specifications

CAS Number

[3085356-41-5]

UNSPSC

12352005

Target

Apoptosis; NF-κB

Related Pathways

Apoptosis; NF-κB

Field of Research

Cancer

Smiles

OC1=C(C=C(C=C1)/C=C2CN(C3CC3)C/C(C\2=O)=C\C4=CC=C(C=C4)C)OC

Molecular Formula

C24H25NO3

Molecular Weight

375.46

References & Citations

[1]Khor PY, et al. Discovery of New Non-Symmetrical Heterocyclic Pentanoid Derivatives Targeting Metastatic Triple-Negative Breast Cancer. Bioorg Med Chem Lett. 2025 Aug 1;123:130232.