THNAN69
THNAN69 is a potent chemical probe degrader targeting LIMK2, with a DC50 value of 1 nM. THNAN69 can be used for the study of diseases driven by LIMK2 overexpression or dysregulation, such as cancers and ocular diseases[1].
Product Specifications
UNSPSC
12352005
Target
LIM Kinase (LIMK)
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
CC1=C(N2CCC(NC2=O)=O)C=CC=C1OCC3=CN(N=N3)CCCCC(NC4=NC=C(S4)C5=CC(C(F)F)=NN5C6=C(Cl)C=CC=C6Cl)=O
Molecular Formula
C32H29Cl2F2N9O4S
Molecular Weight
744.60
References & Citations
[1]Kamal Rayees Abdul Azeez, et al. Discovery and development of a potent LIMK2 isoform-specific degrader. SSRN Electronic Journal. 2024, Preprint (SSRN: 5412751)
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LIMK2
Curated Selection
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