Antifungal agent 135

Antifungal agent 135 (Compound C2), an antifungal agent, is a Succinate dehydrogenase (SDH) inhibitor with an IC50 of 1.99 μM. Antifungal agent 135 has potent antifungal activities against Valsa mali, Sclerotinia sclerotiorum and Phytophthora capsici with EC50s of 0.280, 1.11 and 0.130 mg/L, respectively. Antifungal agent 135 shows protective and curative activities against P. capsici and V. mali by effectively disrupting hyphal structural integrity and inhibiting mycelial growth[1].

Product Specifications

UNSPSC

12352005

Target

Fungal; Succinate Dehydrogenase

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

O=C(NN(C(C1=CC=CC(C(F)(F)F)=C1)=O)C2=NC(C(F)(F)F)=CS2)C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3

Molecular Formula

C21H9F12N3O2S

Molecular Weight

595.36

References & Citations

[1]Xu Z, et al. Design, Synthesis, and Antimicrobial Evaluation of Novel Thiazolyl-Based Compounds Incorporating Bioactive Amide and Hydrazide Groups. J Agric Food Chem. 2025 Sep 24;73 (38) :23973-23984.