CDK9-IN-42

CDK9-IN-42 is a potent and selective CDK9 inhibitor with an IC50of 3.8 nM. CDK9-IN-42 can inhibit the growth of cancer cells and induce apoptosis by downregulating Myc-1 and c-Myc. CDK9-IN-42 can be used for the research of cancer, such as breast and lungcancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Caspase; CDK; c-Myc; PARP

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

FC1=CC(OC)=C(C2=NC=NC(NC3=CC(CS(C)(=NC(C4=CN=CS4)=O)=O)=CC=C3)=N2)C=C1

Molecular Formula

C22H19FN6O3S2

Molecular Weight

498.55

References & Citations

[1]Liu Y, et al. Design, Synthesis, and Biological Evaluation of Sulfonamide Derivatives as Potent CDK9 Inhibitors. ACS Med Chem Lett. 2025 Aug 26;16 (9) :1860-1867.