HIV-1-IN-87

HIV-1-IN-87 (Compound 11x) is a dual-site HIV-1 inhibitor targeting the non-nucleoside reverse transcriptase inhibitor binding pocket (NNIBP) and its adjacent site (NNIAS) . HIV-1-IN-87 has potent antiviral activities against wild-type and mutant strains (such as L100I, K103N and Y181C) (EC50s: 4.1-150 nM) . HIV-1-IN-87 can be used for HIV-1 infections like acquired immune deficiency syndrome (AIDS) research[1].

Product Specifications

UNSPSC

12352005

Target

HIV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

CC1=CC(/C=C/C#N)=CC(C)=C1OC2=C(C=NC(NC3=CC=C(C=C3)C#N)=N2)C#CC(NCCCN4CCOCC4)=O

Molecular Formula

C32H31N7O3

Molecular Weight

561.63

References & Citations

[1]Ji X, et al. Design, synthesis, and biological evaluation of dual-site HIV-1 inhibitors simultaneously targeting the NNRTI binding pocket and an adjacent site with favorable resistance profiles. Bioorg Chem. 2025 Sep;164:108924.