Sal-AMP

Sal-AMP is an acyl-adenylate intermediate. Sal-AMP can be loaded by MbtA on to the thiolation domain of MbtB. Sal-AMP can be used in tuberculosis research[1][2].

Product Specifications

CAS Number

[863238-52-2]

UNSPSC

12352208

Target

Drug Intermediate

Related Pathways

Others

Field of Research

Infection

Smiles

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OC(C4=CC=CC=C4O)=O)(O)=O)O3

Molecular Formula

C17H18N5O9P

Molecular Weight

467.33

References & Citations

[1]Duckworth BP, et al. Development of a selective activity-based probe for adenylating enzymes: profiling MbtA Involved in siderophore biosynthesis from Mycobacterium tuberculosis. ACS Chem Biol. 2012 Oct 19;7 (10) :1653-8. |[2]Ferguson L, et al. Integrated Target-Based and Phenotypic Screening Approaches for the Identification of Anti-Tubercular Agents That Bind to the Mycobacterial Adenylating Enzyme MbtA. ChemMedChem. 2019 Oct 4;14 (19) :1735-1741.