CDK12 ligand-3
CDK12 ligand-3 is a molecular glucose degrading agent that targets the CDK12 protein (DC50 = 35 nM) . CDK12 ligand-3 degrades CDK12, CDK13 and their regulatory subunit Cyclin K in a concentration dependent manner, and inhibits RNA polymerase II CTD (Ser2) phosphorylation. CDK12 ligand-3 exhibits potent anti proliferative activity against Jurkat cells. CDK12 ligand-3 can be used for research on cancers such as leukemia[1].
Product Specifications
CAS Number
[3093763-27-7]
UNSPSC
12352005
Target
CDK; Molecular Glues
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Field of Research
Cancer
Smiles
ClC1=CN=C(N[C@H]2CN(CCC2)C(C3=CC=CC=C3)=O)N=C1NC4=CC=CC=C4S(=O)(C(C)C)=O
Molecular Formula
C25H28ClN5O3S
Molecular Weight
514.04
References & Citations
[1]Zhuang Z, et al. Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders. Angew Chem Int Ed Engl. 2025 Sep 15;64 (38) :e202508427.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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