TD-522

TD-522 is a potent and selective molecular glue GSPT1 degrader, with a DC50 of 0.269 nM. TD-522 exhibits strong anti-proliferative effects and induces apoptosis in acute myeloid leukemia (AML) and diffuse large B-cell lymphoma (DLBCL) cells. TD-522 suppresses tumor growth in a TMD-8 xenograft model. TD-522 can be used for AML and DLBCL research[1].

Product Specifications

CAS Number

[2417647-40-4]

UNSPSC

12352005

Target

Apoptosis; Molecular Glues

Related Pathways

Apoptosis; PROTAC

Field of Research

Cancer

Smiles

CC(C1=CC=C2N=NN(C(C2=C1)=O)C3CCC(NC3=O)=O)NC(NC4=CC=C(C(Cl)=C4)C(C)(C)C)=O

Molecular Formula

C25H27ClN6O4

Molecular Weight

510.97

References & Citations

[1]Takwale AD, et al. Structure-activity relationship analysis of novel GSPT1 degraders based on benzotriazinone scaffold and its antitumor effect on xenograft mouse model. Bioorg Chem. 2022 Oct;127:105923.