TR-213

TR-213 is a potent molecular glue degrader that targets Cyclin K (CDK) . TR-213 induces 91% and 56% decrease in CDK12 and Cyclin at 1 μM. TR-213 can inhibit RNA polymerase II activity and regulates alternative polyadenylation (APA) activity. TR-213 can be used for the research of cancer[1].

Product Specifications

CAS Number

[2980502-40-5]

UNSPSC

12352005

Target

CDK; DNA/RNA Synthesis; Molecular Glues

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Field of Research

Cancer

Smiles

N#CC1=CC=CC(C2=CCN(CC2)C3=NC(C4=CC(OC)=C(C=C4N3)OC)=O)=C1

Molecular Formula

C22H20N4O3

Molecular Weight

388.42

References & Citations

[1]Sano O, et al. Novel quinazolin-4 (3H) -one based Cyclin K degraders regulate alternative polyadenylation activity. Biochem Biophys Res Commun. 2023 Oct 8;676:6-12.