CCI17464

CCI17464 is a selective, orally active EP4 partial agonist with a pKi of 7.1. CCI17464 can be used in a Freund's complete adjuvant (FCA) acute rat inflammatory pain model and shows complete reversal of allergic reactions[1].

Product Specifications

CAS Number

[325780-75-4]

UNSPSC

12352005

Target

Prostaglandin Receptor

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=C(CC1=CC=C(N2C(C3=C(C4=C(C(OCC)=C3C2)C=CC=C4)OCC)=O)C=C1)O

Molecular Formula

C24H23NO5

Molecular Weight

405.44

References & Citations

[1]Healy MP, et al. Discovery of {4-[4,9-bis (ethyloxy) -1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl]-2-fluorophenyl}acetic acid (GSK726701A), a novel EP4 receptor partial agonist for the treatment of pain. Bioorg Med Chem Lett. 2018 Jun 1;28 (10) :1892-1896.