Basivarsen linker

Basivarsen linker is a linker used in HY-177452 Zeleciment basivarsen for coupling a TfR1-binding Fab Zeleciment (HY-P990780) and an antisense oligonucleotide. Zeleciment basivarsen is an antibody-oligonucleotide conjugate (AOC) designed to target mutant nuclear myotonic dystrophy protein kinase (DMPK) RNA for RHase H-mediated degradation to correct splicing. It is used for the study of myotonic dystrophy type 1 (DM1) .

Product Specifications

CAS Number

[2763758-01-4]

UNSPSC

12352005

Target

Antibody-Oligonucleotide Conjugates (AOCs)

Related Pathways

Antibody-drug Conjugate/ADC Related

Field of Research

Others

Smiles

NC(CCOCCOCCOCCOCCNC(OC[C@H]1[C@]2([H])[C@@]1([H])CCC3=C(N(N=N3)CCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(C=C4)COC(N)=O)=O)=O)=O)CC2)=O)=O

Molecular Formula

C50H81N11O16

Molecular Weight

1092.24

References & Citations

[1]Weeden, Timothy; Hilderbrand, Scott; Spring, Sean; Shen, Peiyi; Vieira, Benjamin. Methods of preparing protein-oligonucleotide complexes. WO2022051665A1