FAPI-800CW
FAPI-800CW is a near-infrared (NIR) fluorescent-labeled fibroblast activation protein (FAP) inhibitor. FAPI-800CW shows specific uptake in inflamed paws in collagen-induced arthritis (CIA) model mice. FAPI-800CW can be used for in vivo molecular imaging of FAP expression in inflammatory diseases such as rheumatoid arthritis (RA) to monitor joint inflammation and disease activity[1].
Product Specifications
UNSPSC
12352005
Target
FAP
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Purity
99.40
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C[C@H]1C#N)(CN1C(CNC(C2=CC=NC3=C2C=C(C=C3)OCCCN4CCN(CC4)C(CCCCC[N+]5=C(/C=C/C6=C(/C(CCC6)=C/C=C7N(CCCCS(=O)([O-])=O)C8=C(C/7(C)C)C=C(S(=O)(O)=O)C=C8)OC9=CC=C(S(=O)(O)=O)C=C9)C(C)(C)C%10=CC(S(=O)(O)=O)=CC=C5%10)=O)=O)=O)F
Molecular Formula
C70H80F2N8O17S4
Molecular Weight
1471.68
References & Citations
[1]Narain R, et al. Increased imaging ligand hydrophilicity and improved pharmacokinetic properties provides enhanced in vivo targeting of fibroblast activation protein. Npj Imaging. 2024 Aug 2;2 (1) :24.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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